This newly released trailer for the Binding of Isaac remake is disturbingly haunting. It reminds me of that scene from Willy Wonka and the Chocolate Factory where they're going through the tunnel of hell and nightmares.
Rebirth, as the name suggests, is a remake of the original rogue-like dungeon crawler, developed by Edmund McMillen. It will cover all of the content from the original and expansion, as well as another expansion full of new content. The remake/expansion will include 2 new characters, over a hundred new items, and new floors. It will also feature local co-op and the ability to save a playthrough (the game is randomly generated) so you can challenge your friends.
The game is in good hands--instead of being made with Flash, it's being developed in a new engine by Nicalis, the company responsible for the wonderfully done Cave Story remake. Rebirth is being developed for Steam, PS4, and Vita, and according to Nicalis, they're also working on bringing it to Xbox and 3DS. The graphic style of the remake is going to be pixelated 16-bit, a humorous and ironic decision by McMillen.
The Binding of Isaac wiki keeps track of everything that's been announced about the remake so far. The Binding of Isaac: Rebirth is scheduled for a 2014 release.