Cabin In The Woods director Drew Goddard is in the process of making a deal with to direct Sony's Spider-Man spin-off, Sinister Six. He's already writing the script for the film, so it makes sense that he would come on board to direct it as well. It was kind of expected. The guy did an amazing job with Cabin In The Woods, and I would love to see him take on a film that focuses on these villains.
The studio is looking to build up their own Marvel-style cinematic universe with all of these Spider-Man characters. It will basically be The Avengers of villains, consisting of Doctor Octopus, Electro, Kraven the Hunter, Mysterio, Sandman, and The Vulture. Those are the original villains. They could change things around, though, and swap out a couple for Lizard and Green Goblin. Many of these characters have been teased in the trailers for The Amazing Spider-Man 2.
Then, of course, there's Venom, who is getting his own film that is currently being developed by Alex Kurtzman, Roberto Orci, and Ed Solomon.
Spider-Man has done very well for Sony, and they have to keep making movies or the rights to these characters will revert to Marvel. I wouldn't care if that happened at all, but the studio obviously wants to hold on to them so that they can keep making their money.
There's no word on when Sinister Six or Venom will be released, but it will most likely happen after Spider-Man 3, which is set for release on June 10th, 2016. I think it will happen before the fourth film, though, which will be released on May 4th, 2018.
It will be interesting to see how this movie comes together, and if Spider-Man will be involved with the story in any way. Goddard is a talented individual, and I have confidence that he'll create some really special and cool for the fans.
On a side note, Goddard and Joss Whedon have worked together before – on Cabin in the Woods and Buffy the Vampire Slayer. I can't help but have a fanboy hope that they could help merge these two cinematic universes. Seeing Spider-Man in an Avengers film would be one of the greatest things ever. I know it will never happen, though.